Dosing and Administration

High-Dose Bolus Regimen

Administer intravenously 25 mcg/kg within 5 minutes and then 0.15 mcg/kg/min for up to 18 hours. In patients with creatinine clearance (CrCl) ≤60 mL/min, give 25 mcg/kg bolus within 5 minutes followed by an infusion of 0.075 mcg/kg/min for up to 18 hours.

 

Administration

The following videos provide detailed instructions on how to use Aggrastat High-Dose Bolus.
View now to see best practices for storing, dosing, and administering Aggrastat.

 

Bolus Vial
Please see Important Safety information below and at the end of the video.

 

100 mL Vial / 250 mL Bag (50 mcg/mL Units)
Please see Important Safety information below and at the end of the video.

 

Drug Compatibilities

Aggrastat can be administered in the same intravenous line as heparin, atropine sulfate, dobutamine, dopamine, epinephrine hydrochloride (HCl), famotidine injection, furosemide, lidocaine, midazolam HCl, morphine sulfate, nitroglycerin, potassium chloride, and propranolol HCl. Do not administer Aggrastat through the same IV line as diazepam. Do not add other drugs or remove solution directly from the Intravia bag with a syringe.

 

Instructions for Intravia Bags

To open, first tear off foil overpouch. Plastic may be opaque due to moisture absorption during sterilization, but will diminish gradually. Check for leaks by squeezing inner bag firmly. Discard if any leaks are found or the sterility is suspect. Do not use unless solution is clear and seal is intact. Do not use bags in series connections. Such use can result in air embolisms by drawing air from the first bag if it is empty of solution.

 

Instructions for 100 mL Vial

Ensure seal is intact. Remove vial cap. Place vial on a flat surface, insert a vented IV set and open the vent. Hang bottle by plastic hanger and adjust flow for appropriate dosing.

 

Dosing Formulas

Bolus (mL)
All patients

(using 250 mcg/mL bolus vial)

 

= 25 mcg/kg x body weight (kg)


250 mcg/mL

Bolus (mL)
All patients

(using 50 mcg/mL units)

 

 

= 25 mcg/kg x body weight (kg)


50 mcg/mL

 

 

Infusion (mL/h)
Patients with CrCl >60 mL/min
(using 50 mcg/mL units)

 

 

 

= 0.15 mcg/kg/min x body weight (kg) x 60 min/h


50 mcg/mL

Infusion (mL/h)
Patients with CrCl ≤60mL/min

(using 50 mcg/mL units)

 

 

= 0.075 mcg/kg/min x body weight (kg) x 60 min/h


50 mcg/mL

 

Dosing Calculator

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Results:

1.Bolus (Using 250 mcg/mL Bolus Vial)

2.Infusion (Using 50 mcg/mL Units)

1.Bolus (Using 50 mcg/mL Units)

2.Infusion (Using 50 mcg/mL Units)

 

DISCLAIMER
By using this resource, you agree to the following: This Dosing Calculator is being provided “AS IS” and is intended for use only by qualified healthcare providers. All calculations should be confirmed before use. Medicure makes no claims as to the accuracy of the information contained herein. The information being provided is not a substitute for clinical judgment. Neither Medicure, nor any other party involved in the preparation or publication of this site, shall be liable to you or others for any decisions made or actions taken by you or others in reliance on this information.